Major Revision回复信结构（逐条回应+修改标记+补充实验）

Major Revision 回复信核心结构（三件套）

一次完整的大修回复应包含以下三个部分，请将它们打包成一个压缩文件上传：

1. 回应信（Response Letter / Rebuttal Letter）： 核心文件，逐条回复所有意见。
2. 修订稿（Revised Manuscript）： 两种版本。
   • 清洁版（Clean）： 无标记的最终稿。
   • 标记版（Highlighted / Marked）： 用不同颜色高亮所有修改处。
3. 补充材料（Supplementary Materials，如适用）： 新加的图表、数据等。

以下将重点详解最核心的 回应信（Response Letter） 的写法。

回应信（Response Letter）标准结构

一份专业的回应信通常遵循以下四部分结构，确保编辑和审稿人能够一目了然。

第一部分：致编辑的信（Cover Letter to Editor）

这是一封写给编辑的简短概要信，体现礼貌和全局观。

核心要素：

• 礼貌开场： 感谢编辑给予修改机会。
• 概括态度： 表明你高度重视审稿意见并进行了认真修改。
• 简要说明： 提及修改的全面性（如补充实验、全文润色等）。
• 引导查阅： 说明随信附上的详细回复和修订稿。

模板：

Dear Dr. [编辑姓氏],

Thank you very much for your letter and the reviewers’ constructive comments on our manuscript entitled “[您的论文标题]” (Manuscript ID: [稿件编号]). We sincerely appreciate the opportunity to revise our work.

We have carefully considered all the comments and made extensive revisions to the manuscript accordingly. These revisions include: [选择性简要列举1-2项最重要的修改，如: conducting additional experiments as suggested by Reviewer 2, thoroughly polishing the language, and restructuring the discussion section]. We believe that the manuscript has been significantly improved as a result.

In this revision, you will find:

1. Our point-by-point responses to all comments (below).
2. A marked version of the manuscript with all changes highlighted in yellow.
3. A clean version of the revised manuscript.

We hope that the revisions meet with your approval. Thank you again for your time and consideration.

Sincerely, [您的姓名] [您的职位/单位]

第二部分：修改要点清单（List of Changes / Summary of Revisions）

这是一个可选的但非常加分的部分，位于逐条回复之前。它以清单形式让编辑和审稿人快速了解修改工作量。

模板：

Summary of Major Revisions

• Experiment: Added a new experiment to investigate the effect of X on Y, as suggested by Reviewer 2 (see new Figure 5 and Results section, page 12).
• Analysis: Performed additional statistical analysis (ANCOVA) to control for potential confounding factors, as suggested by Reviewer 1 (see Statistical Analysis section, page 6).
• Discussion: Significantly expanded the discussion to address the limitations of the study and its broader implications, as suggested by Reviewer 3 (see Discussion, pages 15-16).
• Language: The entire manuscript has been professionally edited for language and clarity.

第三部分：逐条回应（Point-by-Point Response）

这是回复信的灵魂，必须清晰、严谨。

黄金法则：

• 三要素缺一不可： 审稿人意见原文 -> 您的详细回复 -> 修改位置说明。
• 格式清晰： 使用字体、颜色或缩进区分审稿人意见和您的回复。
• 分类策略： 采用我们上一轮讨论的“接受/争议/不可行”三类策略进行回应。

标准格式模板：

Responses to Reviewers

Response to Comments from Reviewer #1

Comment 1: [粘贴审稿人1的第一条意见原文] Response: We thank the reviewer for this insightful suggestion. We agree that [表明你认同的态度]. Accordingly, we have [详细说明你做了什么修改]. This change can be found in the [方法/结果/讨论] section on page [X], lines [Y-Z] of the revised manuscript. （如果修改复杂，直接引用修改后的句子） The revised text now reads: “[引用修改后的原文]”.

Comment 2: [粘贴审稿人1的第二条意见原文] Response: [根据意见类型，套用不同的回应策略…]

Response to Comments from Reviewer #2

Comment 1: [粘贴审稿人2的意见原文] Response: We are grateful to the reviewer for raising this important point. We have now conducted additional experiments to address this concern. [详细描述补充实验的过程和结果]. The results are presented in the new Figure 4 and described in the Results section (page [X], lines [Y-Z]). As shown, [简要说明新数据如何支持了你的结论或回应了审稿人的关切].

第四部分：结尾

最后可以简单表示感谢和期待。

We sincerely thank the editors and reviewers for their time and valuable comments, which have greatly improved our manuscript. We look forward to hearing from you regarding our submission.

关键要点与最佳实践

1. 态度决定一切： 始终保持尊重、感激和诚恳的态度。“We thank the reviewer for this constructive comment.” 是万能开头。
2. 修改处处可查： 务必在回复中指明修改发生的具体位置（页码、行号），并在修订稿中高亮标记。这是回应有效性的关键证据。
3. 补充实验是“王牌”： 如果审稿人要求补实验，而你有条件完成，这将是极大加分项。在回复中详细描述实验设计、结果和结论，并整合到论文中。
4. 不要遗漏任何一条意见： 即使是一个拼写错误，也要认真回复“We have corrected this typo.” 这表明你细致入微。
5. 有理有据地“Argue”： 对于不同意的意见，不要直接拒绝。要先感谢，然后用数据和文献委婉地解释你的理由，并尽可能在文中做一些补充说明以示尊重。